- WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
edgeR p-value < 0.01 and fold change > 4.
Transcripts that showed significantly increased expression in animals with pan-neuronal expression of human alpha-Synuclein(A53T) (aex-3p-alpha-syn (A53T)), comparing to in N2 animals.
- WBPaper00038060:SUMO-1_downregulated
The Linear Models for Microarray Data (Limma) package using linear model fitting for statistical testing with empirical Bayes variance smoothing procedure were applied to detection of differentially expressed genes in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 nematodes when compared to N2. The obtained p values were corrected for multiple testing using Benjamini and Hochberg false discovery rate procedure. For downstream analysis, genes with FDR corrected p < 0.001 were used including 1,805 probe sets from aex-3::His-SUMO-1 versus N2 comparison (899 under- and 906 overexpressed) and 1,342 probe sets from myo-4::His-SUMO-1 versus N2 comparison (774 under and 568 overexpressed).
Genes showing < 0.5-fold down-regulated expression (p < 0.001) both in aex-3::His-SUMO-1 or myo-4::His-SUMO-1 C. elegans.
- WBPaper00038060:SUMO-1_upregulated
The Linear Models for Microarray Data (Limma) package using linear model fitting for statistical testing with empirical Bayes variance smoothing procedure were applied to detection of differentially expressed genes in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 nematodes when compared to N2. The obtained p values were corrected for multiple testing using Benjamini and Hochberg false discovery rate procedure. For downstream analysis, genes with FDR corrected p < 0.001 were used including 1,805 probe sets from aex-3::His-SUMO-1 versus N2 comparison (899 under- and 906 overexpressed) and 1,342 probe sets from myo-4::His-SUMO-1 versus N2 comparison (774 under and 568 overexpressed).
Genes showing > 1.5-fold up-regulated expression (p<0.001) both in aex-3::His-SUMO-1 and myo-4::His-SUMO-1 C. elegans.
- WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
edgeR p-value < 0.01 and fold change > 4.
Transcripts that showed significantly decreased expression in animals with pan-neuronal expression of both human amyloid beta (snb-1p-Amyloid-beta(1-42) + mtl-2p-GFP) and human alpha-Synuclein(A53T) (aex-3p-alpha-syn (A53T)), comparing to in N2 animals.
- WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
edgeR p-value < 0.01 and fold change > 4.
Transcripts that showed significantly increased expression in animals with pan-neuronal expression of both human amyloid beta (snb-1p-Amyloid-beta(1-42) + mtl-2p-GFP) and human alpha-Synuclein(A53T) (aex-3p-alpha-syn (A53T)), comparing to in N2 animals.
- WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
DESeq2, fold change >= 2, FDR < 0.05.
Transcripts that showed significantly increased expression in global RPOA-2-depleted L1 animals (degron-GFP-rpoa-2;eft-3p-TIR1, +IAA), compared to controls (degron-GFP-rpoa-2,+IAA).