CDK-8 is the catalytic subunit of the Mediator complex and is known to regulate specific gene programs in yeast and in cultured mammalian cells; because no study has yet identified CDK-8 regulated genes in an in vivo animal model, we performed genome wide expression profiling on
cdk-8 null mutant C. elegans worms to identify CDK-8 regulated genes and developmental and/or physiological gene programs.