gene: rnt-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Expressed in body wall musculature; intestine; neurons; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and osteochondrodysplasia (multiple). Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3).
gene: rund-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables small GTPase binding activity. Involved in several processes, including dense core granule maturation; positive regulation of behavior; and regulation of transport. Located in several cellular components, including Golgi trans cisterna; neuronal cell body; and perinuclear region of cytoplasm. Expressed in uterus. Is an ortholog of human RUNDC1 (RUN domain containing 1).