gene: nphp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including determination of adult lifespan; male mating behavior; and non-motile cilium assembly. Located in cilium. Expressed in ciliated neurons; cloacal ganglion; postcloacal sensillum; and sensory neurons. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 1. Is an ortholog of human NPHP1 (nephrocystin 1).
gene: nphp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in several processes, including determination of adult lifespan; male mating behavior; and plasma membrane bounded cell projection organization. Located in ciliary basal body; ciliary transition zone; and non-motile cilium. Expressed in cloacal ganglion; neurons; and tail ganglion. Used to study Meckel syndrome and nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 4. Is an ortholog of human NPHP4 (nephrocystin 4).