Enables metalloendopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Expressed in head. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy and restrictive dermopathy 1. Is an ortholog of human ZMPSTE24 (zinc metallopeptidase STE24).
Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective).
Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective).
Enables cysteine-type endopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Is an ortholog of human RCE1 (Ras converting CAAX endopeptidase 1).