gene: glp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including cytoplasmic streaming; positive regulation of cell population proliferation; and regulation of gene expression. Located in cytoplasm; endomembrane system; and lateral plasma membrane. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including AB lineage cell; anus; germ line; neurons; and somatic nervous system. Used to study cancer and obesity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including NOTCH1 (notch receptor 1); NOTCH2 (notch receptor 2); and NOTCH3 (notch receptor 3).