gene: ced-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatidylinositol phosphate binding activity; proline-rich region binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and left/right axis specification. Located in cytoplasm and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Expressed in intestinal cell and tail. Is an ortholog of human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3).