gene: arx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Located in cell leading edge and cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); glioblastoma; and opisthorchiasis. Is an ortholog of human ACTR3 (actin related protein 3).
gene: copa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport and intracellular protein transport. Predicted to be located in Golgi membrane. Predicted to be part of COPI vesicle coat. Expressed in distal tip cell and head. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Is an ortholog of human COPA (COPI coat complex subunit alpha).