encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (I) isoform (OMIM: 176710), an alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; dpy-18
has a critical role in hydroxylation of cuticle collagens during collagen synthesis; dpy-18
, in complex with phy-2
, is essential for the survival of the C. elegans; dpy-18
mutations alone result in a mild dumpy phenotype; expressed dpy-18
act in parallel influencing the connection between epidermis and muscle during embryonic development; deletion of dpy-18
causes aggregation of collagen IV in body wall muscles in elongated embryos and triggers the loss of tissue integrity in ten-1
is expressed throughout the hypodermis, head and posterior neurons.