gene: aap-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein kinase binding activity. Involved in dauer larval development; determination of adult lifespan; and insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Expressed in anchor cell; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; SHORT syndrome; arthritis (multiple); and carcinoma (multiple). Is an ortholog of human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).