gene: bbs-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable patched binding activity and smoothened binding activity. Involved in non-motile cilium assembly. Acts upstream of or within intraciliary retrograde transport and protein localization to cilium. Located in axoneme; ciliary basal body; and neuron projection. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome; alcohol use disorder; and obesity. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 1 and obesity. Is an ortholog of human BBS1 (Bardet-Biedl syndrome 1).