- gene: xpa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum group A. Is an ortholog of human XPA (XPA, DNA damage recognition and repair factor).
- gene: syf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in generation of catalytic spliceosome for first transesterification step. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Expressed in head and tail. Is an ortholog of human XAB2 (XPA binding protein 2).
- gene: wwp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Expressed in GABAergic neurons; cholinergic neurons; coelomocyte; somatic neurons; and vulval muscle. Is an ortholog of human WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2).
- gene: xpg-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 5'-flap endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; respiratory system cancer (multiple); and xeroderma pigmentosum group G. Is an ortholog of human ERCC5 (ERCC excision repair 5, endonuclease).
- gene: ercc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity and identical protein binding activity. Involved in UV-damage excision repair and base-excision repair. Predicted to be located in nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).
- gene: xpf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables enzyme binding activity. Involved in DNA damage response; meiotic chromosome segregation; and regulation of multicellular organismal development. Predicted to be part of nucleotide-excision repair factor 1 complex. Expressed in body wall musculature; embryonic cell; germ cell; and neurons. Used to study Cockayne syndrome; Fanconi anemia; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group Q; XFE progeroid syndrome; and polyneuropathy due to drug. Is an ortholog of human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit).
- transgene: jsEx1013
Caenorhabditis elegans [NM1860 (mcherry::
zyx-1); NM1874 (
zyx-1::GFP), 1:1]