gene: hars-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Involved in germ cell development; nematode larval development; and translation. Predicted to be located in cytosol and mitochondrion. Used to study Perrault syndrome and sensory peripheral neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Is an ortholog of human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial).