gene: sel-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein kinase binding activity. Involved in several processes, including apical protein localization; negative regulation of Notch signaling pathway; and regulation of vulval development. Located in perinuclear region of cytoplasm. Expressed in several structures, including ganglia; pharyngeal-intestinal valve; rectum; somatic nervous system; and vulva. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in common variable immunodeficiency 8 and stomach cancer. Is an ortholog of human LRBA (LPS responsive beige-like anchor protein) and NBEA (neurobeachin).
gene: lag-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Notch binding activity. Involved in several processes, including maintenance of dauer; regulation of basement membrane organization; and regulation of cell population proliferation. Located in cell projection membrane and neuronal cell body membrane. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neurons; and vulval cell.