gene: unc-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable high voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; negative regulation of transforming growth factor beta receptor signaling pathway; and response to heat. Located in presynaptic active zone membrane. Expressed in several structures, including body wall musculature; excretory canal; nerve ring; neurons; and pharyngeal muscle cell. Used to study migraine. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system (multiple); brain disease (multiple); and episodic ataxia type 2. Is an ortholog of human CACNA1B (calcium voltage-gated channel subunit alpha1 B).