Predicted to enable several functions, including DNA-binding transcription factor activity; NAD+ nucleosidase activity; and signaling adaptor activity. Predicted to be involved in several processes, including ATP metabolic process; negative regulation of MyD88-independent toll-like receptor signaling pathway; and response to axon injury. Is an ortholog of C. elegans
tir-1. In C. elegans,
tir-1 is involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression.