gene: dkf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in defense response to bacterium; determination of adult lifespan; and signal transduction. Acts upstream of with a negative effect on protein import into nucleus. Located in cytoplasmic side of plasma membrane and cytosol. Part of serine/threonine protein kinase complex. Expressed in AVF; NSM; head neurons; lumbar neurons; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital heart disease. Is an ortholog of human PRKD1 (protein kinase D1); PRKD2 (protein kinase D2); and PRKD3 (protein kinase D3).