gene: unc-29 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse] [Search on AGR]
Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including neuromuscular synaptic transmission; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion involved in locomotory behavior. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; head neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; autosomal dominant nocturnal frontal lobe epilepsy 1; and congenital myasthenic syndrome (multiple). Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).