gene: atl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Seckel syndrome 1; gastrointestinal system cancer (multiple); and pancreatic cancer. Is an ortholog of human ATR (ATR serine/threonine kinase).