gene: lin-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Expressed in vulval precursor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Lewy body dementia; and schizophrenia. Is an ortholog of human ELK1 (ETS transcription factor ELK1).
gene: sel-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and regulation of mesodermal cell fate specification. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.