Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of growth. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head neurons and pseudocoelom. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and female reproductive organ cancer (multiple). Is an ortholog of human SMAD4 (SMAD family member 4).
Is affected by several genes including daf-2; met-2; and sma-4 based on RNA-seq and microarray studies. Is affected by paraquat and Ketamine based on RNA-seq studies.