gene: ser-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including reproductive behavior; response to heat; and signal transduction. Located in plasma membrane. Expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; and obsessive-compulsive disorder. Is an ortholog of human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B).
gene: sca-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; calcium ion import; and chemical homeostasis. Located in cytoplasmic vesicle and endomembrane system. Expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; hypertension (multiple); and keratosis (multiple). Is an ortholog of human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3).