gene encodes an ortholog of the human mucolipin 1 gene; cup-5
is required for viability, endo-lysosomal transport and the normal degradation of lysosomes; cup-5
mutants also show increased cell death, which might be a secondary consequence of lysosomal dysfunction; the inactivation of mrp-4
which is a ABCC transporter rescues most of the defects in cup-5
mutants, suggesting that the accumulation of ABC transporters in the absence of cup-5
, may contribute to the lysosomal defects; cup-5
localizes to lysosomes.