encodes one of eleven C. elegans caenacin peptides; cnc-2
functions as a secreted antimicrobial peptide in the innate immune response: cnc-2
expression is strongly induced in the epidermis upon infection by the fungal pathogen and overexpression of cnc-2
promotes survival after D. coniospora infection; cnc-2
expression is also induced upon infection by the Gram negative bacterium Serratia marcescens; cnc-2
expression is positively regulated by the DBL-1 TGF-beta homolog, the SMA-6/DAF-4 TGF-beta receptor, and the SMA-3, but not SMA-2 and SMA-4, SMAD protein.