gene: trp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Expressed in ASER; SMDDL; SMDDR; SMDVL; and SMDVR. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1H; lung cancer; and stomach cancer. Is an ortholog of human TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5).