gene: nhr-25 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse] [Search on AGR]
Enables armadillo repeat domain binding activity. Involved in molting cycle and positive regulation of nematode male tail tip morphogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in several structures, including excretory system; gonad; hypodermal cell; tail; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Zellweger syndrome; gonadal dysgenesis (multiple); and primary ovarian insufficiency 7. Is an ortholog of human NR5A1 (nuclear receptor subfamily 5 group A member 1) and NR5A2 (nuclear receptor subfamily 5 group A member 2).