gene: lev-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).
gene: lev-9 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable peptidase inhibitor activity. Located in extracellular space. Expressed in body wall musculature; cholinergic neurons; dorsal nerve cord; nerve ring; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; IgA glomerulonephritis; autoimmune disease (multiple); and coronary artery disease (multiple). Is an ortholog of several human genes including C4BPA (complement component 4 binding protein alpha); CR1 (complement C3b/C4b receptor 1 (Knops blood group)); and CR1L (complement C3b/C4b receptor 1 like).
gene: lev-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in several structures, including DD neuron; anal depressor muscle; ganglia; head neurons; and uterine-vulval cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit).
gene: lev-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).