gene: frm-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Expressed in PVDL and PVDR. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Human FRMPD4 enables phosphatidylinositol-4,5-bisphosphate binding activity. Is predicted to encode a protein with the following domains: WW domain; Ras association (RalGDS/AF-6) domain; FERM central domain; FERM superfamily, second domain; FERM/acyl-CoA-binding protein superfamily; Ubiquitin-like domain superfamily; PDZ superfamily; Band 4.1 domain; and PDZ domain. Is an ortholog of human FRMPD1 (FERM and PDZ domain containing 1); FRMPD3 (FERM and PDZ domain containing 3); and FRMPD4 (FERM and PDZ domain containing 4).
gene: plc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1).