gene: pdr-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including determination of adult lifespan; negative regulation of engulfment of apoptotic cell; and protein metabolic process. Located in mitochondrial outer membrane and neuronal cell body. Part of ubiquitin ligase complex. Expressed in muscle cell and neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; Parkinson's disease 2; and female reproductive organ cancer (multiple). Is an ortholog of human PRKN (parkin RBR E3 ubiquitin protein ligase).