gene: hmp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and left/right axis specification. Located in adherens junction and nucleus. Part of catenin complex. Expressed in distal tip cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; gastrointestinal system cancer (multiple); germ cell cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human JUP (junction plakoglobin).