gene: hlh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of metabolic process; and sex differentiation. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including distal tip cell; enteric muscle; lateral ganglion; ray precursor cell; and terminal bulb. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; and agammaglobulinemia (multiple). Is an ortholog of human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4).