gene: msh-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable double-strand/single-strand DNA junction binding activity and mismatched DNA binding activity. Involved in DNA damage response; maintenance of DNA repeat elements; and reproduction. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); carcinoma (multiple); and cervix uteri carcinoma in situ. Is an ortholog of human MSH2 (mutS homolog 2).