gene: gsa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be part of heterotrimeric G-protein complex. Expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; Alzheimer's disease; dystonia 25; and pseudohypoparathyroidism (multiple). Is an ortholog of human GNAL (G protein subunit alpha L).