Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in axon regeneration;
p38MAPK cascade; and regulation of developmental growth. Located in cytoplasm. Expressed in head; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4).