gene: hif-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to caloric restriction; determination of adult lifespan; and heat acclimation. Located in nucleus. Expressed widely. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); familial erythrocytosis 4; and hypertension (multiple). Is an ortholog of human EPAS1 (endothelial PAS domain protein 1) and HIF3A (hypoxia inducible factor 3 subunit alpha).