gene: dog-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA helicase activity. Involved in DNA metabolic process; regulation of DNA-templated DNA replication; and reproduction. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1).