gene: srgp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activator activity; protein self-association; and small GTPase binding activity. Involved in negative regulation of cell migration; negative regulation of phagocytosis, engulfment; and regulation of cell-cell adhesion. Located in adherens junction and cell cortex. Expressed in hypodermis; nerve ring; somatic cell; and spermatheca. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Is an ortholog of human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1) and SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2).