gene: exc-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cell morphogenesis; epithelial cell development; and regulation of tube size. Located in several cellular components, including actin cytoskeleton; apical cortex; and cell body. Expressed in excretory cell; hermaphrodite gonad; neurons; pharyngeal muscle cell; and rectal epithelium. Used to study Charcot-Marie-Tooth disease type 4H and X-linked Aarskog syndrome. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4H; X-linked Aarskog syndrome; and invasive ductal carcinoma. Is an ortholog of several human genes including FGD1 (FYVE, RhoGEF and PH domain containing 1); FGD3 (FYVE, RhoGEF and PH domain containing 3); and FGD4 (FYVE, RhoGEF and PH domain containing 4).