gene: daf-2 [Browse genome (BioProject PRJNA13758)] [Legacy GBrowse] [Search on AGR]
Enables PTB domain binding activity; SH2 domain binding activity; and protein kinase binding activity. Involved in several processes, including dauer exit; regulation of developmental process; and regulation of macromolecule metabolic process. Acts upstream of with a negative effect on protein import into nucleus. Located in cytoplasmic vesicle; neuronal cell body; and plasma membrane bounded cell projection. Is spanning component of plasma membrane. Expressed in several structures, including XXX cell; amphid neurons; coelomocyte; gonad; and nerve ring. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; kidney cancer (multiple); liver disease (multiple); and prostate disease (multiple). Is an ortholog of human IGF1R (insulin like growth factor 1 receptor); INSR (insulin receptor); and INSRR (insulin receptor related receptor).