gene: daf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable activin binding activity; activin receptor activity, type I; and transforming growth factor beta receptor activity. Involved in several processes, including dauer entry; determination of adult lifespan; and response to bacterium. Predicted to be located in plasma membrane. Predicted to be part of activin receptor complex. Expressed in several structures, including distal tip cell; ganglia; inner labial sensillum; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glaucoma (multiple); and hypertension (multiple). Is an ortholog of human ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1).