gene: aspm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calmodulin binding activity and protein domain specific binding activity. Involved in establishment of meiotic spindle orientation; meiotic spindle organization; and regulation of protein localization. Located in spindle midzone and spindle pole. Used to study microcephaly. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); primary autosomal recessive microcephaly 5; and visual epilepsy. Is an ortholog of human ASPM (assembly factor for spindle microtubules).