gene: mec-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including positive regulation of multicellular organismal process; response to mechanical stimulus; and thigmotaxis. Located in axon; microtubule; and neuronal cell body. Expressed in nerve ring; neurons; and in male. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; amyotrophic lateral sclerosis type 22; and lissencephaly 3. Is an ortholog of human TUBA3C (tubulin alpha 3c) and TUBA3D (tubulin alpha 3d).
sequence feature: WBsf717875
Caenorhabditis elegans This is a predicted enhancer region. These are intergenic TF-binding sites >500 bp from a gene start which overlap a TSS cluster, excluding regions that appear to be unannotated promoters based on having a signature of high H3K4me3/low H3K4me1. Nearest downstream gene=C44B11.3. Surounding gene organisation=tandem