gene: brc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin protein ligase activity. Involved in several processes, including DNA repair; cellular response to ionizing radiation; and nuclear chromosome segregation. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human BRCA1 (BRCA1 DNA repair associated).