Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Enriched in ASK based on single-cell RNA-seq studies. Is affected by several genes including sir-2.1; clk-1; and hda-2 based on microarray and RNA-seq studies.
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in sensory perception of chemical stimulus. Predicted to be located in membrane.