gene: acr-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane and regulation of muscle contraction. Located in synapse. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).