gene: lad-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables semaphorin receptor activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and regulation of axon guidance. Located in plasma membrane. Expressed in lumbar neurons and nerve ring neurons. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; MASA syndrome; carcinoma (multiple); and pheochromocytoma. Is an ortholog of human L1CAM (L1 cell adhesion molecule).