gene: egl-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cGMP-dependent protein kinase activity. Involved in several processes, including regulation of multicellular organismal process; regulation of signal transduction; and response to oxygen-containing compound. Located in cytosol and nucleus. Expressed in several structures, including marginal cell; nerve ring; neurons; spermatheca; and vulval muscle. Used to study ciliopathy. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Is an ortholog of human PRKG1 (protein kinase cGMP-dependent 1).