- gene: T24B8.7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cysteine-type deubiquitinase activity. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Is an ortholog of human USP24 (ubiquitin specific peptidase 24).
- gene: Y66D12A.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 107. Is an ortholog of human STEEP1 (STING1 ER exit protein 1).
- gene: snn-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity. Involved in neuromuscular synaptic transmission. Located in presynaptic periactive zone. Expressed in epithelial cell and nervous system. Human ortholog(s) of this gene implicated in several diseases, including X-linked epilepsy with variable learning disabilities and behavior disorders; major depressive disorder; and non-syndromic X-linked intellectual disability 50. Is an ortholog of human SYN3 (synapsin III).
- gene: F33D11.10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA helicase activity and mRNA binding activity. Involved in nuclear mRNA surveillance. Predicted to be located in nucleolus. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in intellectual disability and pancreatic cancer. Is an ortholog of human EIF4A3 (eukaryotic translation initiation factor 4A3).
- gene: eif-4A3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in translational initiation. Predicted to be located in nucleolus. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in intellectual disability and pancreatic cancer. Is an ortholog of human EIF4A3 (eukaryotic translation initiation factor 4A3).
- gene: inpp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and positive regulation of flagellated sperm motility. Located in cytoplasm. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Is an ortholog of human INPP5K (inositol polyphosphate-5-phosphatase K).
- gene: smc-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable cohesin loader activity and double-stranded DNA binding activity. Predicted to be involved in mitotic sister chromatid cohesion. Part of chromatin and cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Is an ortholog of human SMC3 (structural maintenance of chromosomes 3).
- gene: hrpf-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in Sjogren's syndrome; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human GRSF1 (G-rich RNA sequence binding factor 1) and HNRNPF (heterogeneous nuclear ribonucleoprotein F).
- gene: dhhc-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Is an ortholog of human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18) and ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9).
- gene: T14B4.3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable signaling receptor activity. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to be located in external side of plasma membrane. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Is an ortholog of human ATP6AP2 (ATPase H+ transporting accessory protein 2).