Phenotypes:

Alleles for which the sequence change is known are listed in boldface.

The following phenotypes have been observed in atx-2:

Phenotype Entities Affected Supporting Evidence
germ cell morphology variantRNAi:
hermaphrodite germline proliferation variantRNAi:
egg laying variantRNAi:
65646
Remark: number of eggs laid was reduced
Strain: N2
paper: Kiehl TR, Shibata H & Pulst SM, 2000
details
maternal sterileRNAi:
cleavage furrow initiation defective early embRNAi:
cell membrane organization biogenesis variantRNAi:
85627
Remark: Internal PI4,5P2 debris in germ cells. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.; PI4,5P2 accumulation in nucleus of germ cells. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.; PI4,5P2 accumulation in cytoplasm or nucleus of germ cells. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.
Strain: OD95
paper: Green RA et al., 2011
details
reduced brood sizeRNAi:
RAB-11 recycling endosome morphology variantRNAi:
91001
Genotype: unc-119(ed3) III; cbgIs91[pPept-1:pept-1::DsRed;unc-119(+)]; cbgIs98[pPept-1:GFP::rab-11.1;unc-119(+)]
Remark: PEPT-1::DsRED accumulated in fuzzy or irregularly shaped structures; GFP::RAB-11 recycling endosome (RE) morphology appears diffuse or GFP::RAB-11 is cytosolically distributed; Autofluorescent lysosome-related organelles (AF/LROs) appear diffuse
paper: Winter JF et al., 2012
details
germline proliferation variantRNAi:
diakinesis progression during oogenesis variantRNAi:
85627
Remark: Premature diakinesis.
Strain: OD95
paper: Green RA et al., 2011
details
meiosis variantRNAi:
62715
Genotype: gld-2(q497) gld-1(q485); glp-1(q175)
Remark: A substantial increase in meiotic entry in gld-2 gld-1; glp-1 atx-2(RNAi) germlines compared with gld-2 gld-1; atx-2(RNAi) germlines.
paper: Maine EM, Hansen D, Springer D & Vought VE, 2004
details
nuclei enlargedRNAi:
85627
Remark: Nuclear size moderately large in proximal germ line (>120% normal).; Nuclear size large in proximal germ line (>140% normal).
Strain: OD95
paper: Green RA et al., 2011
details
sterileAllele:
  • tm4373
    Curator: Karen Yook
    Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan.
    details
  • tm3562
    Curator: Karen Yook
    Remark: Classified as lethal or sterile by the National Bioresource Project of Japan.
    details
RNAi:
85627
Strain: OD95
paper: Green RA et al., 2011
details
diplotene region organization variantRNAi:
85627
Remark: Shortened diplotene region.
Strain: OD95
paper: Green RA et al., 2011
details
embryonic lethalRNAi:
lysosome-related organelle morphology variantRNAi:
91001
Genotype: unc-119(ed3) III; cbgIs91[pPept-1:pept-1::DsRed;unc-119(+)]; cbgIs98[pPept-1:GFP::rab-11.1;unc-119(+)]
Remark: PEPT-1::DsRED accumulated in fuzzy or irregularly shaped structures; GFP::RAB-11 recycling endosome (RE) morphology appears diffuse or GFP::RAB-11 is cytosolically distributed; Autofluorescent lysosome-related organelles (AF/LROs) appear diffuse
paper: Winter JF et al., 2012
details
masculinization of germlineRNAi:
largeRNAi:
112057
Remark: Downregulation of atx-2 increases cell and body size
paper: Bar DZ et al., 2016
details
protein expression variantRNAi:
germ cell compartment expansion variantRNAi:
85627
Remark: Premature compartment expansion prior to turn, compartments still visible.
Strain: OD95
paper: Green RA et al., 2011
details
transgene subcellular localization variantRNAi:
91001
Genotype: unc-119(ed3) III; cbgIs91[pPept-1:pept-1::DsRed;unc-119(+)]; cbgIs98[pPept-1:GFP::rab-11.1;unc-119(+)]
Remark: PEPT-1::DsRED accumulated in fuzzy or irregularly shaped structures; GFP::RAB-11 recycling endosome (RE) morphology appears diffuse or GFP::RAB-11 is cytosolically distributed; Autofluorescent lysosome-related organelles (AF/LROs) appear diffuse
paper: Winter JF et al., 2012
details
lethalAllele:
  • tm4373
    Curator: Karen Yook
    Remark: Classified as lethal OR sterile by the National Bioresource Project of Japan.
    details
  • tm3562
    Curator: Karen Yook
    Remark: Classified as lethal or sterile by the National Bioresource Project of Japan.
    details
reproductive system morphology variantRNAi:
64285
Remark: size of gonad reduced
paper: Ciosk R, DePalma M & Priess JR, 2004
details
male germline proliferation variantRNAi:
fat content variantRNAi:
112058
details
germ cell compartment size variantRNAi:
85627
Remark: Compartments distal to turn in gonad vary in size.
Strain: OD95
paper: Green RA et al., 2011
details
oocyte septum formation variantRNAi:
85627
Remark: Oocyte juctions are irregular.
Strain: OD95
paper: Green RA et al., 2011
details
embryo osmotic integrity defective early embRNAi:

Phenotype not observed:
The following phenotypes have been reported as NOT observed in atx-2
Phenotype Entities Affected Supporting Evidence
embryonic development variantRNAi:
6170
Remark: DIC phenotype -- Embryonic development normal
paper: Gonczy P et al., 2000
details
maternal sterileRNAi:
reduced brood sizeRNAi:
68829
Genotype: efl-1(se1)
paper: Lehner B et al., 2006
details
body size variantRNAi:
meiosis variantRNAi:
embryonic lethalRNAi:
feminization of germlineRNAi:
masculinization of germlineRNAi:
life span phenotypeRNAi:
  • 112232
    Genotype: eat-2(ad1116)
    Remark: Does not affect lifespan of N2 and eat-2(ad1116) under tested conditions.
    paper: Bar DZ et al., 2016
    details
  • 112059
    Remark: Does not affect lifespan of N2 and eat-2(ad1116) under tested conditions.
    Strain: N2
    paper: Bar DZ et al., 2016
    details
nematode phenotypeRNAi:
lethalAllele:
tm3397
Curator: Karen Yook
Remark: Classified as homozygous viable by the National Bioresource Project of Japan.
details
larval growth variantRNAi:
postembryonic development variantRNAi:
6170
Remark: DIC phenotype -- Embryonic development normal
paper: Gonczy P et al., 2000
details
actin organization biogenesis phenotypeRNAi:
64285
Remark: Not required for actin cytoskeleton organization.
paper: Ciosk R, DePalma M & Priess JR, 2004
details
movement variantRNAi:
organism morphology variantRNAi:

Interaction-based phenotypes:

The following phenotypes are indirectly caused or affected by some perturbation of atx-2 in the context of a genetic interaction :


Overexpression:
Overexpression of the atx-2 gene results in the following phenotypes.
Phenotype Entities Affected Supporting Evidence
small
ygEx111
Caused by gene: atx-2
Curator: Daniel Z. Bar
Paper evidence: Bar DZ et al., 2016
Remark: Over-expression of atx-2 decreases cell and body size
details
fat content variant
ygEx111
Caused by gene: atx-2
Curator: Daniel Z. Bar
Paper evidence: Bar DZ et al., 2016
details