Phenotypes:

Alleles for which the sequence change is known are listed in boldface.

The following phenotypes have been observed in atln-1:

Phenotype Entities Affected Supporting Evidence
endoplasmic reticulum morphology variantRNAi:
WBRNAi00112386
Genotype: GFP::SP12 (hjIs14)
Paper evidence: Klemm RW et al., 2013
Remark: In atln-1 RNAi-treated animals the Endoplasmic Reticulum is depleted from the lateral regions of cells.
details
germ cell compartment expansion variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Incomplete compartment expansion at turn in gonad.; Premature compartment expansion prior to turn, compartments still visible.
Strain: OD95
details
oocytes lack nucleusRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: anucleate compartments/oocytes
Strain: OD95
details
germ cell compartment size variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Compartments distal to turn in gonad vary in size.
Strain: OD95
details
multiple nuclei oocyteRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: multinucleated oocytes
Strain: OD95
details
nuclear appearance variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Irregular nuclear shape.
Strain: OD95
details
chromosome condensation variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Chromatin hypercondensed in oocytes.; Oocyte chromatin abnormally condensed.; Pachytene chromatin abnormally condensed.
Strain: OD95
details
fat associated body size decreasedRNAi:
WBRNAi00112388
Genotype: GFP::DGAT-2 (hjSi56)
Paper evidence: Klemm RW et al., 2013
Remark: Animals had smaller lipid droplets after RNAi. Authors showed that there is a sustained requirement for ATLN-1 in Maintaining lipid droplet size in C. elegans.
details
sterileRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Strain: OD95
details
oocyte morphology variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Oocytes are rounded.; Oocytes are irregular in size.
Strain: OD95
details
germline nuclear positioning variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Nuclei irregularly positioned in germline compartments.; Nuclei irregularly positioned in proximal ooctyes.
Strain: OD95
details
oocytes smallRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Strain: OD95
details
oogenesis variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Oocyte budding delayed. In wildtype as as they round the turn in the gonad, oocytes bud off of the rachis tip, here there is a delay in this process.
Strain: OD95
details
nuclei smallRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Nuclear size small in the proximal germ line (21 - 50 percent of normal).; Nuclear size moderately small in the proximal germ line (51 - 70 percent of normal).
Strain: OD95
details
germ cell compartment anucleateRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: anucleate compartments/oocytes
Strain: OD95
details
diakinesis progression during oogenesis variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Premature diakinesis.
Strain: OD95
details
oocyte number decreasedRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Strain: OD95
details
germ cell compartment largeRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Enlarged compartments distal to turn in gonad.
Strain: OD95
details
rachis wideRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Strain: OD95
details
maternal sterileRNAi:
WBRNAi00057450
Paper evidence: Sonnichsen B et al., 2005
details
cell membrane organization biogenesis variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Soluble PI4,5P2 in proximal oocytes. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.; Internal PI4,5P2 debris in germ cells. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.; Soluble PI4,5P2 throughout gonad. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.; PI4,5P2 accumulation in cytoplasm or nucleus of germ cells. PI4,5P2 is phosphatidylinositol 4,5-bisphosphate which is normally a phospolipid component of cell membranes.
Strain: OD95
details
diplotene progression during oogenesis variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Progression through diplotene abnormal.
Strain: OD95
details
fat associated bodies variantRNAi:
WBRNAi00112387
Genotype: GFP::DGAT-2 (hjSi56)
Paper evidence: Klemm RW et al., 2013
Remark: Lipid droplets were largely excluded from the basolateral cell cortex after RNAi. In control animals, the lipid droplets were uniformly distributed throughout the cell.
details
apoptosis reducedRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Apoptosis reduced in the germline.
Strain: OD95
details
germ cell partition morphology variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Partitions incomplete in pachytene region.
Strain: OD95
details
gonad vesiculatedRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Enlarged vesicles at proximal end of rachis.
Strain: OD95
details
pronuclear nuclear appearance defective early embRNAi:
WBRNAi00057450
Paper evidence: Sonnichsen B et al., 2005
details
rachis morphology variantRNAi:
WBRNAi00085582
Paper evidence: Green RA et al., 2011
Remark: Enlarged vesicles at proximal end of rachis.; Rachis constriction in proximal region delayed.
Strain: OD95
details

Phenotype not observed:
The following phenotypes have been reported as NOT observed in atln-1

Interaction-based phenotypes:

The following phenotypes are indirectly caused or affected by some perturbation of atln-1 in the context of a genetic interaction :


Overexpression:
Overexpression of the atln-1 gene results in the following phenotypes.